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desvenlafaxine will increase the stage or influence of codeine by affecting hepatic enzyme CYP2D6 metabolism. Use Warning/Keep track of. Desvenlafaxine inhibits CYP2D6; with increased desvenlafaxine doses (ie, four hundred mg) decrease the CYP2D6 substrate dose by approximately 50%; no dosage adjustment needed with desvenlafaxine doses seven consec